Since mid-1938, the National Socialist authorities exercised great pressure on the leadership of the Friedrich-Luisen-Hospice. The home was to be converted into a non-Jewish institution.

In September of 1938, Bettina Falk, who had been managing the home since 1924, was forced to cease use of the name Friedrich-Luisen-Hospice. With the onset of World War II, the fate of the Jewish children’s home was sealed. The house was used as a hospital. Trude Schwarz moved back to her parents in Rexingen.

Bettina Falk and her sister Emilie Falk, who were the last to leave the home and had moved to Frankfurt, were deported to Estonia on September 24, 1942, and murdered there.